This previous month, we’ve lined loads of esearch information and details about conferences, however now we’ve got some information of our personal. Right here’s what’s been taking place within the rejuvenation biotechnology world.
LEAF Information
Lifespan.io and SENS Research Foundation Unite to Launch a New Powerhouse in Aging Research: In the present day, we and SENS Analysis Basis are excited to announce the completion of their merger, forming a brand new 501(c)(3) non-profit: Lifespan Analysis Institute.
Interviews
I Dined with Bryan Johnson and Didn’t Die: Don’t Die is an idea or philosophy that Bryan has been creating. It shares some premises with Ray Kurzweil’s concept of singularity, which states that as a result of ever-increasing tempo of technological progress, a future is close to that’s utterly unimaginable – and therefore, unpredictable from our present standpoint.
Advocacy and Evaluation
NILAR: A4LI’s Response to NIH Reform Proposal: The longevity advocacy and lobbying group has submitted detailed suggestions to the congressional proposal to switch NIA with the Nationwide Institute on Dementia – and now you possibly can signal the petition.
Less Talk, More Work: Foresight/LBF Longevity Workshop 2024: When Foresight Institute and Longevity Biotech Fellowship joined forces, a one-of-a-kind longevity occasion emerged. Foresight Institute has been perfecting the workshop system for years. In keeping with Foresight CEO Allison Duettmann, it’s been fairly profitable, with quite a few concepts, which had been initially thrown round at workshops, changing into tasks and getting funded.
For the 11th Year in Copenhagen: Highlights from ARDD 2024: The Copenhagen-based Ageing Analysis and Drug Discovery Assembly (ARDD) was already monumental, however on the daybreak of its second decade, ARDD’s attendance of researchers, entrepreneurs, and lovers grew even greater and was bought out even sooner, solidifying its iconic standing within the discipline.
Insights from the Roundtable of Longevity Clinics 2024: The hunt to increase human lifespan and enhance healthspan is advancing quickly, and some of the prestigious platforms for driving these discussions is the Roundtable of Longevity Clinics. This annual gathering brings collectively international specialists to trade information on cutting-edge analysis, improvements, and regulatory methods aimed toward enhancing human longevity.
Analysis Roundup
Caffeic Acid Variant May Suppress Bone Deterioration: In Ageing, researchers have described how a by-product of caffeic acid inhibits osteoclasts, the cells that break down bone, which can result in a remedy for osteoporosis.
Combination Therapy Works Against Pancreatic Cancer in Mice: In a brand new examine, a multi-prong remedy mixed with a intelligent supply technique has proven promise towards pancreatic ductal adenocarcinoma, one of many deadliest cancers.
Keto Diets May Help Cognitive Function in Alzheimer’s: The outcomes of 10 independently carried out scientific trials recommend that ketogenic diets have a optimistic influence on the cognitive perform of Alzheimer’s illness sufferers, providing a possible remedy addition for an incurable illness.
Targeting Senescent Cells by Their Surface Markers: New analysis in Ageing Cell has recommended that concentrating on senescent cells based mostly on their floor proteins (surfaceome) could also be efficient in coping with them, because it makes drug improvement extra possible.
Associations Between Professional Sports and Longevity: A brand new examine analyzed how being an elite athlete in numerous sports activities impacts human lifespan. Among the outcomes had been shocking and contradicted standard knowledge.
Blocking a Dopamine Receptor May Improve Memory: Neurological researchers, in Ageing Cell, have deepened our understanding of the mind, explaining how turning off a dopamine receptor could result in higher reminiscence in older individuals.
Medium LDL Levels Associated With Lowest Mortality: A brand new observational examine means that decrease LDL levels of cholesterol are usually not essentially higher. As an alternative, the ratio of triglycerides to HDL could also be extra vital.
How Supplement Formulas, Including NOVOS, Affect Skin Aging: Researchers have examined a number of mixtures of components with anti-aging properties. These mixtures, together with a 12-ingredient formulation created by NOVOS, helped to scale back DNA injury and oxidative stress in human pores and skin cells in cultures.
A New Atlas for Cellular Rejuvenation: In Ageing, researchers from Spain and Luxembourg have described the creation of Single-cell RNA-seq Investigation of Rejuvenation Brokers and Longevity (SINGULAR), an atlas for mobile rejuvenation that describes how interventions have an effect on particular person cells.
Extracellular Vesicles to Fight Liver Fibrosis: Researchers have stuffed extracellular vesicles (EVs) with micro-RNA that’s efficient towards liver fibrosis in mice and printed their breakthrough in Ageing Cell. EVs, which cells use to ship chemical messages and packages to 1 one other, are considerably affected by getting older to the purpose that they’ve been used as biomarkers.
Light Pollution Linked to Alzheimer’s Disease Prevalence: Scientists have discovered a correlation between the depth of nighttime outside lighting, which might disrupt sleep, and Alzheimer’s illness. Extreme ranges of synthetic outside gentle are referred to as “gentle air pollution” and have been linked to sleep disruption, weight problems, melancholy, nervousness, reminiscence dysfunction, atherosclerosis, and most cancers.
Combining Treatments Against Multiple Hallmarks of Aging: Researchers have printed a evaluate of the present state of mixture therapies that deal with a number of Hallmarks of Ageing. A few of these mixed therapies had been discovered to induce larger lifespan extension than single therapies.
The Ventricles of the Heart Age Differently: In Ageing Cell, researchers have printed their findings on how the appropriate ventricle of the guts ages in a different way from the left one. Analysis on getting older has agreed that organs age in a different way, together with all of the arteries, mind tissue, muscle mass, and pores and skin, together with all the numerous digestive and upkeep organs, and this now consists of the ventricles of the guts.
Axolotls’ Epigenetic Clocks Stop Ticking: In a preprint printed in bioRxiv, researchers have printed their findings in making use of an epigenetic clock to the axolotl, a salamander species that doesn’t age like people. Axolotls, and salamanders extra usually, are well-known for his or her regenerative capabilities, with the ability to develop again misplaced limbs.
The Greenland Shark’s Genome Reveals Clues to Its Longevity: Scientists have compiled probably the most full genome ever of the Greenland shark, an exceptionally long-lived species. These sharks, big, slow-moving abyss dwellers, maintain the title of the longest-lived vertebrate at 400 years.
MSC Treatment Improves Age-Related Phenotypes in Rats: In a latest examine, researchers injected rats with mesenchymal stromal cells. They noticed enhancements in aging-related biomarkers and phenotypes in lots of organs. Mesenchymal stromal cells (MSCs) may be obtained from various sources, together with bone marrow, adipose tissue, perinatal tissue, and dental tissues.
Metformin Slows Aging in Non-Human Primates: In a brand new examine, metformin, which has already proven good ends in rodents and in human epidemiological research, alleviated a number of indicators of getting older in male cynomolgus monkeys. Metformin, a well-established anti-diabetes drug, has been touted as a doable geroprotector since a examine recommended that diabetes sufferers on metformin outlived age-matched wholesome controls.
A Likely Beneficial Compound Also Predicts Mortality: Researchers publishing in Ageing have discovered that fibroblast development issue 21 (FGF21), an apparently useful protein naturally produced by the human physique, heralds a larger probability of dying.
Reprogramming Senescent Cells Extends Lifespan in Mice: Dr. Belmonte’s group at Altos Labs focused harassed and senescent cells with partial reprogramming, producing giant will increase in lifespan in male mice. Because the discovery of mobile reprogramming nearly 20 years in the past, lots of hopes have been put into this know-how, and lots of progress has been made.
A Bank of Centenarian Stem Cells: Researchers are maintaining a financial institution of induced pluripotent stem cells (iPSCs) derived from centenarians and their descendants. They describe the aim of this financial institution and its makes use of in Ageing Cell. Centenarians don’t merely dwell for 100 years; they spend extra time in good well being (healthspan) than different individuals.
Study Suggests Mammals’ Lifespan Is Limited by Epigenetics: Juan José Alba-Linares and his analysis crew have printed a preprint examine that examined why totally different animals age at totally different charges. They discovered that epigenetic modifications over time may clarify why some animals dwell longer and estimated an higher restrict for mammalian lifespan.
How Lifesaving Treatments Can Cause Long-Term Harm: A analysis paper printed in Ageing explored a hyperlink between breast most cancers, hematopoietic cell transplants (HCTs), a rise in bodily frailty, and mobile senescence. HCTs and breast most cancers remedy are lifesaving procedures. Nevertheless, chemotherapy in breast most cancers sharply will increase p16INK4a, a key biomarker of mobile senescence, and HCT remedy accelerates getting older.
Associations of daily eating frequency and nighttime fasting duration with biological aging in NHANES: Abnormally lengthy fasting and fewer meals per day had been related to accelerated getting older.
Association between plant and animal protein and biological aging: findings from the UK Biobank: Increased plant protein consumption is inversely related to organic getting older. Though there is no such thing as a affiliation with animal protein, meals with animal proteins displayed a assorted correlation.
Intensity or volume: the role of physical activity in longevity: Depth is a important driver of lowered mortality danger, suggesting that the depth of exercise, relatively than the amount, issues for longevity.
Optimal dose and type of exercise to improve cognitive function in patients with mild cognitive impairment: A community meta-analysis recognized multi-component train as the best intervention for bettering international cognitive and govt perform in sufferers with delicate cognitive impairment.
Hydrolyzed collagen supplementation prior to resistance exercise augments collagen synthesis: Ingesting 15g hydrolyzed collagen rescues the collagen synthesis response in middle-aged males, and 30g augments that response additional.
A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: This complement warrants additional investigation for its potential advantages in selling well being, extending life expectancy, and supporting wholesome getting older.
A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: People with elevated ranges of irritation markers benefited from anthocyanin remedy to reinforce cognitive efficiency, whereas these with decrease ranges didn’t.
Dose–response relationship of dietary Omega-3 fatty acids on slowing phenotypic age acceleration: This examine highlights the potential function of dietary Omega-3 fatty acids in regulating age acceleration and helps the technique of delaying getting older by means of dietary interventions to extend Omega-3 consumption.
Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice: The corresponding peptides could present entry factors for therapies aiming to take care of muscle perform and prolong healthspan.
Hyaluronan and proteoglycan link protein 1 – A novel signaling molecule for rejuvenating aged skin: rhHAPLN1 could act as a novel biomechanical signaling protein to rejuvenate aged pores and skin.
Rejuvenation of aged oocyte through exposure to young follicular microenvironment: These findings present the premise for a future follicular somatic cell-based remedy to deal with feminine infertility.
E5 treatment showing improved health-span and lifespan in old Sprague Dawley rats: In conclusion, this distinctive ‘plasma-derived exosome’ remedy (E5) alone is sufficient to enhance the healthspan and prolong the lifespan of the outdated SD rats considerably.
Information Nuggets
Ora Biomedical Awarded Technology Development Grant: Ora Biomedical, Inc., a pioneering longevity biotechnology firm, is happy to announce that it has been awarded a Small Enterprise Innovation Analysis (SBIR) Section I grant from the Nationwide Institutes of Well being (NIH). The $324,240 grant will help the event of EleGantry, an revolutionary software program and {hardware} infrastructure to enhance analysis high quality.
Insilico Medicine Reports Positive Phase IIa Results for IPF: Insilico Drugs, a clinical-stage generative AI-driven drug discovery firm, introduced optimistic preliminary outcomes from its Section IIa scientific trial evaluating ISM001-055. ISM001-055 is a first-in-class small molecule concentrating on TNIK (Traf2- and Nck-interacting kinase) and was designed using generative AI to deal with idiopathic pulmonary fibrosis (IPF).
Coming Up
Biomarkers of Aging Consortium Announces Second Conference: The Biomarkers of Ageing Consortium is proud to announce its second annual Biomarkers of Ageing Convention, scheduled for November 1-2, 2024, on the Joseph Martin Convention Middle at Harvard Medical College. This occasion stands because the premier convention devoted to all points of biomarkers of getting older, bringing collectively the brightest minds within the discipline.
